Smiling Through the Storm: Laura’s Life with Hyper IgE Syndrome

If you ever meet Laura Zamora, you’ll notice something right away—her joy. It’s not performative. It’s not forced. It’s the kind of joy that’s been tested, refined, and chosen again and again in the face of real struggle.

Laura lives with Hyper IgE Syndrome (HIES), a rare and complex primary immunodeficiency. Sometimes called “Job’s Syndrome,” HIES is characterized by extremely high levels of immunoglobulin E (IgE), a type of antibody that plays a role in allergic responses. For Laura, this diagnosis came with a long list of challenges: chronic infections, holes in her esophagus, fibromyalgia, scoliosis, and more.

But while the symptoms may be intense, Laura’s determination is stronger.

The Reality of Living with HIES

Hyper IgE Syndrome affects fewer than 1 in a million people. Many patients, like Laura, deal with a lifetime of recurring infections, skin and lung issues, and connective tissue complications. It’s a condition that requires constant vigilance and a care plan that evolves with the body’s changing needs.

Despite the medical hurdles, Laura has built a life rooted in resilience. She navigates her condition with courage and grace, all while choosing to focus on what she can do—not just what she’s up against.

Finding Light in a Rare Diagnosis

For many living with rare diseases, isolation can be one of the hardest parts. Few people understand the daily stress of managing an invisible illness. But Laura has become a quiet beacon for others, showing that you can face the hard days and still embrace moments of joy.

At the Yellow Bear Foundation, we believe stories like Laura’s deserve to be told—not just to raise awareness, but to remind others that life with PI is still life. And it can be a beautiful one.

The Power of Early Diagnosis and Community

Though rare, HIES and other forms of PI often show signs early in life. When caught and managed with care, outcomes improve dramatically. Laura’s journey highlights the importance of listening to your body, advocating for answers, and finding strength in support systems.

We’re proud to stand with Laura and so many others who face rare immunodeficiencies with grit, humor, and hope.

Join us in sharing her story—and in building a future where no one facing PI walks alone.

✳️ Story adapted from coverage by the Immune Deficiency Foundation and related sources.